essential for pregnancy
Article page | Family topics |
Researchers have helped solve the mystery of a unique protein called
Pre-implantation Factor - which is produced by healthy embryos to direct embryo
attachment and help the mother adapt to pregnancy.
The protein modulates maternal immunity, promotes attachment of the early
embryo, and influences remodelling of uterine cells.
"Preimplantation Factor appears to be essential for pregnancy to succeed," said
Paidas. "For several decades, investigators have tried to isolate a compound
that was absolutely required for pregnancy. We believe that Preimplantation
Factor is in fact that compound."
In a study of non-pregnant and pregnant uterine stromal cells, which are
positioned directly beneath the uterine lining, researchers found that over 500
maternal genes and several proteins were significantly altered, when exposed to
Preimplantation Factor. Paidas said, profound changes were detected precisely in
those pathways and networks critical for implantation.
Studies are ongoing to establish Preimplantation Factor as a diagnostic test for
pregnancy viability, not only in humans but in animals as well, since it appears
to be universally present in mammals.
There is even greater interest in the potential therapeutic applications, both
in pregnancy and in other conditions such as autoimmune disease and
These findings are published fast track for the benefit of the scientific
community in the current issue of American
Journal of Obstetrics and Gynaecology .
- Courtesy: ANI / Times of India