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Inhalable measles vaccine on way?
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PUNE: Syringes for the treatment of measles in children will soon be replaced by inhalable measles vaccine if the human trials, to be conducted in Pune, succeed. The trials for the inhalable vaccine will begin in the city next month after permission from the Drug Controller General of India (DCGI), Rajeev Dhere, senior director of Pune-based Serum Institute of India (SII), told TOI on Saturday.

Developed by scientists from the University of Colorado (USA), the refined powdered vaccine simply needs to be inhaled. "If found fit on all parameters during the human trials, the inhalable vaccine will make existing measles injections obsolete and the treatment more affordable. Of course, it is a long way to go before we achieve this goal," said Dhere. The SII is the sub-licensee of the powdered inhalable measles vaccine in India.

"The Serum Institute of India knows better about the launch date of the human trial," said the vaccine's creator Robert E Sievers via an e-mail reply to TOI on Saturday.

Sievers is a professor at the department of chemistry and biochemistry and Center for Pharmaceutical Biotechnology at the University of Colorado.

The new vaccine would be particularly useful in poor countries such as India, where two thirds of all measles deaths occur, said Dhere.

More than 1,64,000 children die of the disease every year – the equivalent of almost 450 deaths every day, according to the World Health Organisation.

Called 'carbondioxide assisted nebulisation', the technique of powdered inhalable vaccine has been developed by the University of Colorado and the Aktiv Dry, a pharma research firm in Denvar. Akctiv Dry is the principal investigator.

"The inhalable vaccine has been found fit on all parameters during animal trials in the US," said Dhere.

"The human trials of the vaccine will be in three phases stretching at times to years," said Prasad Kulkarni, additional medical director of SII.

The Bill Melinda Gates Foundation has given grants to Colorado University to develop the vaccine, Dhere said.

- Times of India

 
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