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Venkatraman Ramakrishnan
( An Indo American who received the 2009 Nobel Prize in Chemistry )

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Venkatraman Ramakrishnan, known to most as " Venki" was  born in Chidambaram, Tamil Nadu, India in the year 1952. He is a structural biologist at the MRC Laboratory of Molecular Biology in Cambridge, England.  He received the 2009 Nobel Prize in Chemistry for his pioneering work on ribosome, a cellular machine that makes proteins.

He moved to Baroda (Vadodara) in Gujarat state at the age of three, where he had his schooling. He completed B.Sc in Physics from Maharaja Sayajirao University of Baroda,Gujarat. He wrote entrance exam for getting admission to IIT . But unfortunately he failed to get admission.

Immediately after graduation he moved to the U.S.A., where he obtained his Ph.D. in Physics from Ohio University in 1976.  He then spent two years studying biology as a graduate student at the University of California, San Diego while making a transition from theoretical physics to biology.

Ramakrishnan began work on ribosomes as a postdoctoral fellow with Peter Moore at Yale university. After his post-doctoral fellowship, he initially could not find a faculty position even though he had applied to about 50 universities in the U.S

He continued to work on ribosomes from 1983-95 as a staff scientist at Brookhaven National Laboratory. In 1995 he moved to the University of Utah as a Professor of Biochemistry, and in 1999, he moved to his current position at the MRC  Laboratory of Molecular Biology in Cambridge, England. He has authored several important papers in academic journals.

In the August 26, 2000 issue of Nature, Ramakrishnan and his co-workers published the structure of the small ribosomal subunit of Thermus thermophilus, a heat-stable bacterium related to one found in the Yellowstone hot springs.

With this 5.5 Angstrom-resolution structure, Ramakrishnan's group identified key portions of the RNA and, using previously determined structures, positioned seven of the subunit's proteins.

In the September 21, 2000 issue of Nature, Ramakrishnan published two papers. In the first of these, he presented the 3 Angstrom structure of the 30S ribosomal subunit.

His second paper revealed the structures of the 30S subunit in complex with three antibiotics that target different regions of the subunit. In this paper, Ramakrishnan discussed the structural basis for the action of each of these drugs.

After his postdoctoral fellowship, Ramakrishnan joined the staff of Brookhaven National Laboratory in ther US. There, he began his collaboration with Stephen White to clone the genes for several ribosomal proteins and determine their three-dimensional structures.

Ramakrishnan is a Fellow of the Royal Society, a member of EMBO and the U.S. National Academy of Sciences and a Fellow of Trinity College, Cambridge. He was awarded the 2007 Louis-Jeantet Prize for Medicine, the 2008 Heatley Medal of the British Biochemical Society and the 2009 Rolf-Sammet Professorship at the University of Frankfurt. In 2009, Ramakrishnan was awarded the Nobel Prize in Chemistry along with Thomas A. Steitz and Ada Yonath for his pioneering work on ribosome, a cellular machine that makes proteins.
. He received India's second highest civilian honor, the Padma Vibhushan, in 2010

Ramakrishnan is married to Vera Rosenberry, an author and illustrator of children's books. He has a stepdaughter, Tanya Kapka, who is a doctor in Oregon, and a son, Raman Ramakrishnan, who is a cellist based in New York  (The cello is a bowed string instrument like Violin. A person who plays a cello is called a cellist.)

 
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