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Diabetes may
originate in your intestines
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ANI: Scientists have suggested that problems
controlling blood sugar - the hallmark of
diabetes - may
begin in the intestines.
The finding may upend long-held theories about
the causes of the disease. Because insulin is produced in the pancreas and sugar
is stored in the liver, many scientists have looked to those organs for the
underlying causes of diabetes.
In the new research, scientists at Washington
University School of Medicine in St. Louis studied mice that are unable to make
fatty acid synthase (FAS) in the intestine.
FAS, an enzyme crucial for the production of
lipids, is regulated by insulin, and people with diabetes have defects in FAS.
Mice without the enzyme in the intestines develop chronic inflammation in the
gut, a powerful predictor of diabetes.
"Diabetes may indeed start in your gut," said
principal investigator Clay F. Semenkovich, MD.
"When people become resistant to insulin, as
happens when they gain weight, FAS doesn't work properly, which causes
inflammation that, in turn, can lead to diabetes," he explained.
First author Xiaochao Wei, PhD, and Semenkovich,
the Herbert S. Gasser Professor of Medicine, professor of cell biology and
physiology and director of the Division of Endocrinology, Metabolism and Lipid
Research, collaborated with specialists in gastroenterology and genome sciences
to determine what happens in mice that can't make FAS in their intestines.
"The first striking thing we saw was that the
mice began losing weight. They had diarrhea and other gastrointestinal symptoms,
and when we looked closely at the tissue in the gut, we found a lot of
inflammation," stated Wei, a research instructor in medicine.
Read the full article from Times of India
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