ďWe have previously shown in autopsies of Parkinsonís patients that the abnormal proteins associated with Parkinsonís are consistently found in the submandibular saliva glands, found under the lower jaw,Ē adds Adler. ďMaking a diagnosis in living patients is a big step forward in our effort to understand and better treat patients,Ē says Adler, according to a Mayo Clinic statement. The study involved a group of people averaging 68 years who had Parkinsonís for an average of 12 years. They had responded to Parkinsonís medication and would not have known saliva gland disorders.
Biopsies were taken of two different saliva glands: the submandibular gland and the minor saliva glands in the lower lip. The surgical team was led by Michael Hinni and David Lott, at the Mayo Clinic and the biopsied tissues were tested for evidence of the abnormal Parkinsonís protein by study co-author Thomas Beach, with Banner Sun Health Research Institute.
ďThis procedure will provide a much more accurate diagnosis of Parkinsonís disease than what is now available,Ē Beach says. ďOne of the greatest potential impacts of this finding is on clinical trials, as at the present time some patients entered into Parkinsonís clinical trials do not necessarily have Parkinsonís disease and this is a big impediment to testing new therapies,Ē Beach says.
The abnormal Parkinsonís protein was detected in nine of the 11 patients who had enough tissue to study. Although Parkinsonís disease canít be cured, medications may markedly improve symptoms. These findings will be presented at the American Academy of Neurologyís annual meeting in San Diego in March. ó IANS
( Courtesy: http://www.main.omanobserver.om )