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Treatment of kidney disease in diabetes – new hope with
ketoanalogue
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In a new publication from Jothydev’s Diabetes Research Centre, authors have
described the use of ketoanalogue supplementation in preventing the progression
of kidney disease in diabetes patients. The clinical experience of using
Ketoanalogue supplementation in patients with diabetic kidney disease on Very
Low Protein Diet (VLPD) was brought out by Elsevier Publications in ‘Dietary
Protein Restriction in Chronic Kidney Disease- Very Low–Protein Diet with
Ketoanalogue Supplementation in Diabetic Kidney Disease’. The author Dr.Jothydev
Kesavadev and team discuss 4 impressive clinical cases of patients on
ketoanalogue. An analysis of the data of patients on ketoanalogue at Jothydev’s
Diabetes Research Centre, Trivandrum also shows statistically significant
improvement in creatinine and hemoglobin levels after administration of
ketoanalogue.
 Ketoanalogues
are branched chain amino acids that do not contain nitrogen. When they enter the
circulation, they derive the nitrogen from the tissues. Thus, less nitrogen or
urea is to be formed. However, if enough nitrogen is available from the diet,
these amino acids will not take up the tissue nitrogen and hence when patient is
on ketoanalogue, dietary protein restriction should be strictly followed.
However,
the main limitation of the case studies and experiences presented here from our
centre is the fact that treatment in our center is based on Diabetes Tele
Management System (DTMS®). In this telemedicine follow up program integrating
technology with a multi-disciplinary diabetes team , patients are treated with a
target fasting glucose, post prandial glucose, HbA1c, BP and LDL values
customized to each patient based on multiple parameters. It is well proven that
such intensive modalities can prevent the rapid progression of a renal disease.
This could be a confounding factor in the experiences described in the use of
ketoanalogue.
( Courtesy: http://jothydev.com/ )
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