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Eating peaches may slow breast
cancer growth and spread
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PTI: Peaches have compounds that could be a
novel addition to therapies that reduce the risk of metastasis, the primary
killer in breast and other cancers.
Compounds in peaches can inhibit the growth of
breast cancer cells and their ability to spread, scientists have found.
Researchers from Washington State University and
Texas A&M said the compounds could be a novel addition to therapies that reduce
the risk of metastasis, the primary killer in breast and many other cancers.
The compounds could be given as an extract or,
judging from the doses given to mice in the study, two to three peaches a day.
“I would do three peaches a day,” said Giuliana
Noratto, WSU assistant professor of food science.
The study also underscores the value of good
nutrition in preventing cancer, she said.
“Having enough fruits and vegetables that can
provide these compounds in our diet, we might have a similar preventive effect,”
said Noratto.
In 2009, Noratto and her colleagues at Texas A&M
published a study showing that peach and plum extracts suppressed breast cancer
cells cultured in petri dishes.
For the new study, the researchers implanted
breast cancers cells beneath the skin of mice. The technique, called a xenograft,
is often used to look at the growth of breast cancer cells in a living animal,
mimicking the interactions by which tumours form and progress.
After giving the cells a week to establish, the
researchers fed the mice varying doses of peach polyphenols, compounds that help
plants ward off the damaging effects of the sun’s ultraviolet radiation.
“There are several studies showing that these
compounds act as antioxidants and can therefore protect DNA against damage that
can produce cancer,” said Noratto.
Other researchers have seen the phenomenon,
Noratto said, but she and her colleagues wanted to know if the compounds might
start a cascade of signals that could induce the cancer cells to commit suicide.
“We didn’t even think about metastasis at that
time. The surprise was we analysed lungs and beside the fact that the peach
compounds inhibited the growth of the tumour, they also inhibited the metastasis
levels on the lungs,” Noratto said.
Moreover, after 12 days the researchers saw that
mice fed with high levels of polyphenols had tumours that grew less and without
much of the blood vessel formation that can help cancer cells spread to other
parts of the body.
The tumours in those mice also had less evidence
of enzymes involved in the spread and invasion of cancer.
The doses given to mice, if scaled up to a 60-kg
person, could be supplied by two to three peaches a day or a dietary supplement
of peach polyphenol extract powder.
The study was published in the Journal of
Nutritional Biochemistry.
( Courtesy:
Indian Express )
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