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Salt can be used to treat
Cancer
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Scientists have created a technique which can cause cancer cells to
self-destruct by injecting them with salt.
Researchers from the University of Southampton are part of an
international team that has helped to create a molecule that can cause cancer
cells to die by carrying sodium and chloride ions into the cells.
Synthetic ion transporters have been created before but this is
the first time researchers have demonstrated how an influx of salt into a cell
triggers cell death.
These synthetic ion transporters, described this week in the
journal Nature Chemistry, could point the way to new anti-cancer drugs while
also benefiting patients with cystic fibrosis.
"This work shows how chloride transporters can work with sodium
channels in cell membranes to cause an influx of salt into a cell. We found we
can trigger cell death with salt," said study co-author Professor Philip Gale,
of the University of Southampton.
Cells in the human body work hard to maintain a stable
concentration of ions inside their cell membranes. Disruption of this delicate
balance can trigger cells to go through apoptosis, known as programmed cell
death, a mechanism the body uses to rid itself of damaged or dangerous cells.
One way of destroying cancer cells is to trigger this
self-destruct sequence by changing the ion balance in cells.
Unfortunately, when a cell becomes cancerous, it changes the way
it transports ions across its cell membrane in a way that blocks apoptosis.
The researchers have overcome this by developing the synthetic
way for transporting the ions but unfortunately this also destroys healthy cells
which would have to be overcome for it to be useful in treating cancer.
Prof Jonathan Sessler, at Austin's College of Natural Sciences at
the University of Texas, said: "We have thus closed the loop and shown that this
mechanism of chloride influx into the cell by a synthetic transporter does
indeed trigger apoptosis.
"This is exciting because it points the way towards a new
approach to anti-cancer drug development."
( Courtesy:
Daily Mail )
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